MovDisordV3, Main, Exploration, bibRecord, 003353

Long‐term effects of bilateral subthalamic nucleus stimulation on health‐related quality of life in advanced Parkinson's disease

Identifieur interne : 003353 ( Main/Exploration ); précédent : 003352; suivant : 003354

Long‐term effects of bilateral subthalamic nucleus stimulation on health‐related quality of life in advanced Parkinson's disease

Auteurs : Andrew Siderowf [États-Unis] ; Jurg L. Jaggi [États-Unis] ; Sharon X. Xie [États-Unis] ; Catherine Loveland-Jones [États-Unis] ; Lewis Leng [États-Unis] ; Howard Hurtig [États-Unis] ; Amy Colcher [États-Unis] ; Matthew Stern [États-Unis] ; Kelvin L. Chou [États-Unis] ; Grace Liang [États-Unis] ; Heather Maccarone [États-Unis] ; Tanya Simuni [États-Unis] ; Gordon Baltuch [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-06-06.

RBID : ISTEX:D286EFD594F34D531D9D18AE66D50270FF8F5AB8

Descripteurs français

Pascal (Inist)
- Long terme, Noyau sousthalamique, Parkinson maladie, Pronostic, Qualité vie, Stade avancé, Stimulation cérébrale profonde, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Advanced stage, Aged, Cognition, Deep Brain Stimulation (methods), Deep brain stimulation, Emotions, Female, Health Status, Humans, Levodopa (therapeutic use), Long term, Male, Middle Aged, Motor Activity, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Prognosis, Quality of Life, Quality of life, Subthalamic nucleus, Treatment Outcome, deep brain stimulation, outcomes, quality of life.
MESH :
- chemical , therapeutic use : Levodopa.
- drug therapy : Parkinson Disease.
- methods : Deep Brain Stimulation.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Aged, Cognition, Emotions, Female, Health Status, Humans, Male, Middle Aged, Motor Activity, Quality of Life, Treatment Outcome.

Abstract

We evaluated the long‐term effects of subthalamic nucleus (STN) stimulation on health‐related quality of life (HRQL) in patients with advanced Parkinson's disease (PD). STN stimulation improves motor function and decreases medication requirements in patients with advanced PD. The impact of STN stimulation on HRQL is less well established, especially beyond 1 year after surgery. We report HRQL outcomes for 18 patients with advanced PD. Patients were evaluated with the Parkinson's Disease Questionnaire‐39 (PDQ‐39), the Medical Outcome Study Short Form (SF‐36), and the EuroQol visual analogue scale (VAS) before surgery, 6 months postoperatively, and at a long‐term follow‐up visit (mean, 35.9 months; range, 18–57 months after surgery). Preoperative scores on HRQL measures were compared to results obtained at short‐ and long‐term follow‐up evaluations. The VAS and all domains of the PDQ‐39 except for cognition, communication, and social support showed marked improvements at 6 months after surgery. At the long‐term follow‐up, there were sustained improvements in the VAS (63% improvement; P = 0.0009) and in several domains of the PDQ‐39 [mobility: 20%, P = 0.01; activities of daily living (ADL): 29%, P = 0.005; emotional well‐being: 26%, P = 0.02; stigma: 43%, P = 0.003; and bodily discomfort: 35%, P = 0.007]. At the long‐term evaluation, only the vitality domain of the SF‐36 was significantly improved from baseline (16%; P = 0.01). In this selected group of patients, many of the short‐term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/D286EFD594F34D531D9D18AE66D50270FF8F5AB8/fulltext/pdf

DOI: 10.1002/mds.20786

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Advanced stage</term>
<term>Aged</term>
<term>Cognition</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Deep brain stimulation</term>
<term>Emotions</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Long term</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Prognosis</term>
<term>Quality of Life</term>
<term>Quality of life</term>
<term>Subthalamic nucleus</term>
<term>Treatment Outcome</term>
<term>deep brain stimulation</term>
<term>outcomes</term>
<term>quality of life</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cognition</term>
<term>Emotions</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity</term>
<term>Quality of Life</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Long terme</term>
<term>Noyau sousthalamique</term>
<term>Parkinson maladie</term>
<term>Pronostic</term>
<term>Qualité vie</term>
<term>Stade avancé</term>
<term>Stimulation cérébrale profonde</term>
<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">We evaluated the long‐term effects of subthalamic nucleus (STN) stimulation on health‐related quality of life (HRQL) in patients with advanced Parkinson's disease (PD). STN stimulation improves motor function and decreases medication requirements in patients with advanced PD. The impact of STN stimulation on HRQL is less well established, especially beyond 1 year after surgery. We report HRQL outcomes for 18 patients with advanced PD. Patients were evaluated with the Parkinson's Disease Questionnaire‐39 (PDQ‐39), the Medical Outcome Study Short Form (SF‐36), and the EuroQol visual analogue scale (VAS) before surgery, 6 months postoperatively, and at a long‐term follow‐up visit (mean, 35.9 months; range, 18–57 months after surgery). Preoperative scores on HRQL measures were compared to results obtained at short‐ and long‐term follow‐up evaluations. The VAS and all domains of the PDQ‐39 except for cognition, communication, and social support showed marked improvements at 6 months after surgery. At the long‐term follow‐up, there were sustained improvements in the VAS (63% improvement; P = 0.0009) and in several domains of the PDQ‐39 [mobility: 20%, P = 0.01; activities of daily living (ADL): 29%, P = 0.005; emotional well‐being: 26%, P = 0.02; stigma: 43%, P = 0.003; and bodily discomfort: 35%, P = 0.007]. At the long‐term evaluation, only the vitality domain of the SF‐36 was significantly improved from baseline (16%; P = 0.01). In this selected group of patients, many of the short‐term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable. © 2006 Movement Disorder Society</div>
</front>
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<name sortKey="Loveland Ones, Catherine" sort="Loveland Ones, Catherine" uniqKey="Loveland Ones C" first="Catherine" last="Loveland-Jones">Catherine Loveland-Jones</name>
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Movement Disorders (revue)

Long‐term effects of bilateral subthalamic nucleus stimulation on health‐related quality of life in advanced Parkinson's disease

Long‐term effects of bilateral subthalamic nucleus stimulation on health‐related quality of life in advanced Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

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	Movement Disorders (revue)
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